کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10934148 | 1093882 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development Partner specificity is essential for proper function of the SIX-type homeodomain proteins Sine oculis and Optix during fly eye development](/preview/png/10934148.png)
چکیده انگلیسی
The development of the Drosophila visual system utilizes two members of the highly conserved Six-Homeobox family of transcription factor, Sine oculis and Optix. Although in vitro studies have detected differences in DNA-binding and interactions with some co-factors, questions remain as to what extent the activity for these two transcriptional regulators is redundant or specific in vivo. In this work, we show that the SoD mutation within the Six domain does not abolish DNA-protein interactions, but alters co-factor binding specificity to resemble that of Optix. A mutation in the same region of Optix alters its activity in vivo. We propose that the dominant mutant phenotype is primarily due to an alteration in binding properties of the Sine oculis protein and that distinct partner interactions is one important mechanism in determining significant functional differences between these highly conserved factors during eye development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 286, Issue 1, 1 October 2005, Pages 158-168
Journal: Developmental Biology - Volume 286, Issue 1, 1 October 2005, Pages 158-168
نویسندگان
Kristy L. Kenyon, Donghui Yang-Zhou, Chuan Qi Cai, Susan Tran, Chris Clouser, Gina Decene, Swati Ranade, Francesca Pignoni,