The regulatory factor PcRFX1 controls the expression of the three genes of β-lactam biosynthesis in Penicillium chrysogenum

► A novel transcription factor, PcRFX1, has been characterized in Penicillium chrysogenum. ► PcRFX1 controls the expression of the three penicillin biosynthetic genes. ► Morphology and development seemed not to be controlled by this transcription factor. ► A global analysis of processes putatively regulated by PcRFX1 was carried out.