کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10940219 1095469 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
LKB1/PAR4 protein is asymmetrically localized in mouse oocytes and associates with meiotic spindle
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
LKB1/PAR4 protein is asymmetrically localized in mouse oocytes and associates with meiotic spindle
چکیده انگلیسی
The mouse secondary oocyte is polarized at the ultrastructural and molecular level, but very little is known about mechanisms involved in the establishment of this polarity. We showed that the LKB1 kinase, a mouse homologue of Caenorhabditis elegans PAR4 protein is asymmetrically localized to the animal pole of the mouse oocyte and during oocyte maturation associates with the microtubules of metaphase I and metaphase II meiotic spindles. Therefore, we suggest that LKB1/PAR4 protein, may participate in the polarization of the oocyte and in the regulation of the asymmetry of meiotic divisions during mouse oogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene Expression Patterns - Volume 6, Issue 1, December 2005, Pages 86-93
نویسندگان
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