کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10940369 | 1095479 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulated expression pattern of gremlin during zebrafish development
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Regulated expression pattern of gremlin during zebrafish development Regulated expression pattern of gremlin during zebrafish development](/preview/png/10940369.png)
چکیده انگلیسی
Xenopus laevis Gremlin has been isolated as a novel dorsalizing factor, belonging to a family of secreted proteins with axial patterning activity [Hsu, D.R., Economides, A.N., Wang, X., Eimon, M., Harland, R.M., 1998. The Xenopus dorsalizing factor gremlin identified a novel family of secreted proteins that antagonize BMP activities. Mol. Cell 1, 673-683]. In a search for genes that control development in zebrafish (Danio rerio), we have identified a sequence homologous to Xenopus gremlin. This paper describes the cloning of zebrafish gremlin (grm) and its expression pattern during development. Our results show that grm encodes a maternal transcript, and the zygotic transcription is turned on at the mid-blastula transition (MBT), when grm is detected in the entire blastoderm. In the gastrula grm becomes restricted to the dorsolateral region of the embryo, and during somitogenesis it is strongly expressed in the presomitic mesoderm and developing somites, and in the ventral neural tube. From 24Â hpf to 48Â hpf, we show that grm transcription is downregulated in the whole embryo, even though Grm protein is still present and localized into the entire myotome at 48-72Â hpf. Finally, grm transcript is strongly downregulated in fibroblast growth factor-8 (fgf8) and sonic hedgehog (shh) mutants, thus implicating a putative role of Fgf/Shh signalling loop in grm expression regulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene Expression Patterns - Volume 5, Issue 4, April 2005, Pages 539-544
Journal: Gene Expression Patterns - Volume 5, Issue 4, April 2005, Pages 539-544
نویسندگان
Stefania Nicoli, Claudio N. Gilardelli, Ombretta Pozzoli, Marco Presta, Franco Cotelli,