کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10940838 1095521 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Changes of immunocytic phenotypes and functions from human colorectal adenomatous stage to cancerous stage: Update
ترجمه فارسی عنوان
تغییرات فنوتیپ های ایمنیسیتیک و عملکرد از مرحله آدنوماتوس کولورکتال انسانی به مرحله سرطانی: به روز رسانی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی
It is believed that chronic inflammation as seen in patients with ulcerative colitis significantly increases the colorectal cancer (CRC) risk and functions as the main driving force for the development of colitis associated CRC. Recently, increasing evidences suggest that inflammation is also involved in the processing of sporadic CRCs that mostly develop from the preformed adenomas through a long-term progression. Within the adenoma/CRC tumor microenvironment, high dense immunocytes with significant phenotypic and functional changes have been observed. These cells might produce high level of inflammatory mediators and then affect the adenoma-cancer transition. In this review, we summarize the update on altered phenotypes and inflammatory mediators within the tumor microenvironment from the adenomatous stage to the cancerous stage, and discuss the significance of inflammatory mediators as biomarkers in predicating the progression from the premalignant adenoma lesion to the sporadic CRC lesion and the potential as therapeutic targets.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 220, Issue 10, October 2015, Pages 1186-1196
نویسندگان
, , , , , , , ,