کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10940886 | 1095527 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Safety of a nasal vaccine against Streptococcus pneumoniae using heat-killed Lactobacillus casei as adjuvant
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کلمات کلیدی
PBSLPSL. caseiNasopharynx-associated lymphoid tissuePppATHBS. pneumoniaeRSVLCMMRSPPVALTBALDPINALT - Naltëalanine transaminase - آلانین ترانس آمینازCPR - احیای قلبی ریویAdjuvant - ادجوانت، یاورStreptococcus pneumoniae - استرپتوکوک پنومونیهVaccine safety - ایمنی واکسنTodd Hewitt broth - تولد هیویت بوتهdays post infection - روز پس از عفونتphosphate buffer saline - فسفات بافر شورbronchoalveolar lavage - لارو برونکلو آلوئولارlactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH lipopolysaccharide - لیپوپلی ساکاریدNasal vaccine - واکسن بینیRespiratory syncytial virus - ویروس سنسیتیال تنفسیAntibody - پادتَن یا آنتیبادیAntigen - پادگِن یا آنتیژنC reactive protein - پروتئین واکنشی CPCV - پی وی سی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Safety of a nasal vaccine against Streptococcus pneumoniae using heat-killed Lactobacillus casei as adjuvant Safety of a nasal vaccine against Streptococcus pneumoniae using heat-killed Lactobacillus casei as adjuvant](/preview/png/10940886.png)
چکیده انگلیسی
Streptococcus pneumoniae is a highly important respiratory pathogen that causes infections in children, elderly people and immunocompromised people around the world. Pneumococcal vaccines licensed did not reach to eradicate the pneumococcal infection. In a previous study was demonstrated the effectiveness of a nasal experimental vaccine that consisted in a pneumococcal protective protein A (PppA) co-administrated with heat-killed-Lactobacillus casei (LcM), in mice model of respiratory pneumococcal challenge. In the present work the safety of the experimental vaccine LcMÂ +Â PppA and its components were evaluated through hematological, biochemical and immune parameters in a model infection with S. pneumoniae. Thus, alanine transaminase activity, creatinine levels, lactate dehydrogenase activity, C reactive protein levels, corticosterone levels in serum, total and differential leukocyte counts in blood and bronchoalveolar lavages (BAL) and IgE in BAL, were evaluated. Experimental vaccine: LcMÂ +Â PppA nasally administered does not induce harmful effects in our vaccination-infection model. Studied parameters showed LcMÂ +Â PppA's safety in liver, kidney, pulmonary and systemic levels. Although studies in experimental animals do not guarantee security for the application of the vaccine on humans, they are important evidence for the planning and subsequent clinical trials in humans.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 220, Issue 1, January 2015, Pages 109-116
Journal: Immunobiology - Volume 220, Issue 1, January 2015, Pages 109-116
نویسندگان
Guillermina Almada, Cecilia Haro, Elisa Vintiñi, Marcela Medina,