کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10940941 | 1095535 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phagocytic activity of monocytes, their subpopulations and granulocytes during post-transplant adverse events after hematopoietic stem cell transplantation
ترجمه فارسی عنوان
فعالیت فاگوسیتیک مونوسیت ها، زیرپوپروتئین ها و گرانولوسیت ها در حوادث پس از پیوند پس از پیوند سلول های بنیادی خونریزی
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کلمات کلیدی
E. coliFITCVODHSCTanalysis of co-varianceGvHDANCOVAHBSSEscherichia coli - اشریشیا کُلیstandard deviation - انحراف معیارEBV - اپشتین بار ویروسPediatric patients - بیمار کودکانVeno-occlusive disease - بیماری انسدادی ونGraft-versus-host disease - بیماری مرض در برابر میزبانMonocyte subpopulations - زیر جمعیت جمعیت مونوسیتCompensatory anti-inflammatory response syndrome - سندرم پاسخ ضد التهابی جبرانیcytomegalovirus - سیتومگالوویروسCMV - سیتومگالوویروسphagocytic activity - فعالیت فاگوسیتیکfluorescein isothiocyanate - فلوئورسین ایسوتیوسیاناتCARS - ماشین هاHank's balanced salt solution - محلول نمک متعادل هانکMonocytes - مونوسیتهاEpstein-Barr virus - ویروس Epstein-BarrHematopoietic stem cell transplantation - پیوند مغز استخوان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
Phagocytosis of granulocytes and monocytes presents a major mechanism that contributes to the clearance of pathogens and cell debris. We analyzed the phagocytic activity of the peripheral blood cell monocytes, three monocyte subpopulations and granulocytes before and up to one year after hematopoietic stem cell transplantation, as well as during transplant-related adverse events. 25 pediatric patients and young adults (median age of 11.0 years) with hemato-oncological malignancies and non malignancies were enrolled in the prospective study. Ingestion of fluorescence-labeled Escherichia coli bacteria was used to assess the phagocytic activity of monocytes and their subpopulations and granulocytes by means of flow cytometry in the patient group as well as in a control group (n = 36). During sepsis, a significant increase of phagocytic activity of monocytes (P = 0.0003) and a significant decrease of the phagocytic activity of granulocytes (P = 0.0003) and the CD14+ CD16++ monocyte subpopulation (P = 0.0020) occurred. At the onset of a veno-occlusive disease, a significant increase of phagocytic activity in the CD14++ CD16+ monocyte subpopulation (P = 0.001) and a significant decrease in the phagocytic activity of the CD14++ CD16â monocyte subpopulation (P = 0.0048) were observed. In conclusion, the phagocytic activity of monocytes, their subpopulations and granulocytes might be a useful and easy determinable parameter that enables identification of post-transplant complications after hematopoietic stem cell transplantation. The alterations of phagocytic activity contribute to the altered immune response that accompanies adverse events after hematopoietic stem cell transplantation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 220, Issue 5, May 2015, Pages 605-613
Journal: Immunobiology - Volume 220, Issue 5, May 2015, Pages 605-613
نویسندگان
Michaela Döring, Karin Melanie Cabanillas Stanchi, Annika Erbacher, Susanne Haufe, Carl Philipp Schwarze, Rupert Handgretinger, Michael Hofbeck, Gunter Kerst,