کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10940968 | 1095536 | 2014 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The heterogeneous immune microenvironment in breast cancer is affected by hypoxia-related genes
ترجمه فارسی عنوان
میکرو محیط زیست ایمن ناهمگن در سرطان پستان تحت تاثیر ژن های مرتبط با هیپوکسی قرار دارد
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کلمات کلیدی
STAT-3IDO-1TGF-βMDSCPPIAEpCAMHIFHeme oxygenase-1IL-10PGRFOXP3HO-1TBPInterleukin 10 - اینترلوکین 10indoleamine 2,3-dioxygenase - ایندولامین 2،3-دیوکسژیگنازTIL - بهTAM - تامTransforming Growth Factor Beta - تبدیل بتا فاکتور رشدHuman breast cancer - سرطان سینه انسانNK cell - سلول NKNatural killer cell - سلول قاتل طبیعیMyeloid-derived suppressor cells - سلول های سرکوبگر مشتق از میلوئیدTreg cells - سلولهای TregRegulatory T cells - سلولهای تی تنظیمکنندهVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Hypoxia Inducible Factor - فاکتور قابل تشخیص هیپوکسیsignal transducer and activator of transcription 3 - مبدل سیگنال و فعال کننده رونویسی 3epithelial cell adhesion molecule - مولکول چسبندگی سلولی اپیتلیالImmune microenvironment - میکرو محیط زیست ایمنیSurgical specimen - نمونه جراحیTATA-box binding protein - پروتئین اتصال TATA جعبهEstrogen receptor - گیرنده استروژنProgesterone receptor - گیرنده پروژسترون
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
The immune system constitutes an important first-line defence against malignant transformation. However, cancer mediated immunosuppression inactivates the mechanisms of host immune surveillance. Cancer cells shut down anti-cancer immunity through direct cell-cell interactions with leukocytes and through soluble factors, establishing an immunosuppressive environment for unimpeded cancer growth. The composition of the immunosuppressive microenvironment in breast tumours is not well documented. To address this question, selected immunosuppressive factors were analyzed in tumour specimens from 33 breast cancer patients after surgery. The mRNA expression of selected genes was quantified in fresh tumour samples. Tumour infiltrating leukocytes were characterized by flow cytometry to identify regulatory T cells, myeloid derived suppressor cells, and type 2 macrophages. Statistical analysis revealed several interesting correlations between the studied parameters and clinical features. Overall, a surprisingly high degree of heterogeneity in the composition of the immunosuppressive environment was found across all breast cancer samples which adds to the complexity of this disease. The influence of the hypoxia inducible factors (HIFs) on the immune microenvironment was also addressed. The level of HIFs correlated with hormone receptor status and the expression of several immunosuppressive molecules. Targeting HIFs might not only sensitize breast tumours for radiation and chemotherapies but also interfere with cancer immunosuppression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 219, Issue 2, February 2014, Pages 158-165
Journal: Immunobiology - Volume 219, Issue 2, February 2014, Pages 158-165
نویسندگان
Markus Duechler, Lukasz Peczek, Karolina Zuk, Izabela Zalesna, Arkadiusz Jeziorski, Malgorzata Czyz,