EBP50 promotes focal adhesion turnover and vascular smooth muscle cells migration

► The PDZ-containing scaffolding protein EBP50 promotes vascular smooth muscle cell migration. ► EBP50 scaffolds the interaction between EGFR and FAK resulting in increased FAK phosphorylation. ► EBP50 regulates focal adhesion dynamics. ► These effects expand the understanding of the role of EBP50 on vascular remodeling.