Quantitative proteomics reveals novel functions of osteoclast-associated receptor in STAT signaling and cell adhesion in human endothelial cells

► We examined functional effects of endothelial-derived OSCAR by proteomics. ► Regulated proteins are involved in cell-to-cell signaling and inflammatory response. ► STAT1 and STAT3 are reciprocally activated by OSCAR. ► OSCAR affects adhesion proteins and increases monocyte adhesion. ► The study indicates a novel role of OSCAR in the vascular-immune cross-talk.