OxLDL causes both epigenetic modification and signaling regulation on the microRNA-29b gene: Novel mechanisms for cardiovascular diseases

► In this study we studied mechanisms of oxLDL-upregulated miR-29b. ► OxLDL activated miR-29b from microRNA-29b-1/microRNA-29a cluster gene. ► The LOX-1/Ca2+/ROS/ERK/c-Fos involved in oxLDL-mediated miR-29b overexpression. ► OxLDL-downregulated HDAC1 affected miR-29b expression. ► OxLDL-mediated histone 3 lysine 4 (H3K4) and H3K9 regulated miR-29b expression.