Carbonic anhydrase XIV in the normal and hypertrophic myocardium

► AE3 Cl−/HCO3−- exchanger interacts with the CAXIV enzyme in the heart. ► CAXIV bound to and raised AE3 transport, establishing a physical/functional complex. ► Hypertrophic rat hearts showed elevated CAXIV protein expression. ► AE-mediated HCO3− fluxes increased in the hypertrophic myocardium compared to normal. ► AE3/CAXIV complex formation would render AE3 hyperactive in the hypertrophic heart.