Reduced cardiac CapZ protein protects hearts against acute ischemia-reperfusion injury and enhances preconditioning

► We examined post-ischemic heart function in CapZ transgenic mice. ► CapZ transgenic mice were subjected to acute ischemia-reperfusion. ► Reduced CapZ protein increased post-ischemic function compared to wildtype. ► Protein kinase C activation was altered in CapZ transgenic mice.