Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B

► Protein tyrosine phosphatase 1B inhibition (PTP1Bi) was assessed in heart failure. ► PTP1Bi or gene deficiency reduced adverse LV remodeling, and improved LV function. ► PTP1Bi of gene deficiency reduced cardiac fibrosis and hypertrophy. ► PTP1Bi or gene deficiency restored endothelial function. ► PTP1B may be a new therapeutic target in CHF.