STIM1-dependent store-operated Ca2+ entry is required for pathological cardiac hypertrophy

► SOCE is abundant and robust in neonatal cardiomyocytes, yet absent from adult. ► STIM1 is a required element in the activation of SOCE. ► STIM1 expression - including a novel splicing isoform - is re-activated by stress. ► STIM1-dependent SOCE activates the calcineurin-NFAT signaling pathway. ► STIM1-dependent SOCE is a critical element in pathological hypertrophy.