Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium

► CORM-3 activates stress-responsive transcription factors in the heart. ► CORM-3 upregulates several cardioprotective molecules. ► CORM-3 attenuates the mitochondria-dependent apoptotic pathway. ► CORM-3 attenuates the death-receptor-mediated apoptotic pathway. ► CORM-3 induces a late PC-mimetic cardioprotective milieu in the heart.