Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway

► Bone morphogenic protein 4 (BMP4) induces endothelial cell apoptosis. ► BMP4 increases cleaved caspase-3 activation. ► BMP4 activates BMPR1A and NOX4, leading to ROS production. ► Inhibition of JNK signaling blunts BMP4-induced endothelial cell apoptosis.