Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice

► Constitutive overexpression of SIRT1 impaired cardiac function. ► Constitutive overexpression of SIRT1 disturbed cardiac energy metabolism. ► Constitutive SIRT1 overexpression impaired cardiac mitochondria. ► Constitutive SIRT1 overexpression caused cardiac dysfunction in response to acute pressure overload.