Cyclophilin A affects inflammation, virus elimination and myocardial fibrosis in coxsackievirus B3-induced myocarditis

► In virus myocarditis treatment with a CyPA-inhibitor affects lesion area and collagen. ► Macrophage, T cell infiltration and MMP9 expression were reduced by CyPA inhibition. ► Similar effects are found using CyPA−/− mice in comparison to WT mice. ► CyPA may represent a target to modulate myocardial remodeling in myocarditis.