Keywords: PPi; inorganic pyrophosphate; PPiase; inorganic pyrophosphate hydrolase (E.C. 3.6.1.1; GO; 0004427); PPa; soluble inorganic pyrophosphatases of family I; PPa-ek; soluble inorganic pyrophosphate hydrolase of the family I and eukaryotic type; PPa-pk; solubl
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Keywords: Pin1; Selenium; High-throughput screening; Cancer; PPIase;
Keywords: HpCBF2; Helicobacter pylori cell-binding factor 2; I2CA; indole-2-carboxylic acid; Cell-binding factor 2; Chaperone; Domain motion; Helicobacter pylori; PPIase;
Keywords: ANT; adenine nucleotide translocase; CsA; cyclosporin A; CyP; cyclophilin; Drp1; dynamin-related protein 1; ÎÏm; mitochondrial membrane potential; ERK; extracellular signal regulated kinase; GSK; glycogen synthase kinase; IMM; inner mitochondrial membra
Keywords: ATP; Adenosine triphosphate; PPIase; peptidyl-prolyl isomerase; HIV-1; human immunodeficiency virus type 1; HCV; hepatitis C virus; HBV; hepatitis B virus; AIDS; acquired immunodeficiency syndrome; N-MLV; N-tropic murine leukemia virus; Ref-1; restriction
Keywords: Akt; also known as protein kinase B; ANT; adenine nucleotide translocase; Bad; Bcl-2-associated death promoter; Bak; Bcl-2 homologous antagonist/killer; Bax; Bcl-2-like protein 4; Bcl2; B cell lymphoma 2; Bcl-xL; B-cell lymphoma-extra large; Bid; BH3 inte
Keywords: ABL; Abelson; ALL; acute lymphocytic leukemia; AML; acute myeloid leukemia; APL; acute promyelocytic leukemia; BC; blast crisis; BCR; breakpoint cluster region; BMP; bone morphogenetic protein; CBP; CREB-binding protein; CDK; cyclin dependent kinase; CEBP
Keywords: PPIase; peptidyl-prolyl cis-trans isomerase; NO; nitric oxide; eNOS and iNOS; endothelial and inducible nitric oxide synthase, respectively; VEGF; vascular endothelial growth factor; TGF-β; transforming growth factor-beta; Aβ; amyloid-beta; PBMC; peri
De novo transcriptome assembly and identification of salt-responsive genes in sugar beet M14
Keywords: 1,3-PGA; 1,3-phosphoglycerate; 3-PGA; 3-phosphoglycerate; ACC; aminocyclopropane-1-carboxylate; ACP; acyl carrier protein; Accase; acetyl-coenzyme A carboxylase carboxyl transferase; ADP; adenosine diphosphate; AdoHcyase; adenosylhomocysteinase; AdoMet; S
Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors
Keywords: Pyrimidine; Pin1; Pin1 inhibitor; PPIase; Anti-cancer agents;
FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice
Keywords: αMHC-Cre; α-myosin heavy chain promoter-driven Cre recombinase; BCL2L13; Bcl-2-like protein 13; CCCP; mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone; ER; endoplasmic reticulum; FKBP8; FK506-binding protein 8; GRP78; glucose-regulated p
Structural flexibility in the Helicobacter pylori peptidyl-prolyl cis,trans-isomerase HP0175 is achieved through an extension of the chaperone helices
Keywords: Helicobacter pylori; Parvulin; PPIase; HP0175; Domain motion;
Long-term inhibition of cyclophilin D results in intracellular translocation of calcein AM from mitochondria to lysosomes
Keywords: Cyclophilin D; Calcein AM; Mitochondria; Lysosomes; AM; acetoxymethyl ester; BCECF; 2â²,7â²-bis-(2-carboxyethyl)-5-(and-6)-carboxy-fluorescein; 5-CFDA; 5(6)-carboxyfluorescein diacetate; CypD; cyclophilin D; DMEM; Dulbecco's modified Eagle's medium; FDA
The crystal structure of the Hsp90 co-chaperone Cpr7 from Saccharomyces cerevisiae
Keywords: Hsp90; heat shock protein 90; TPR domain; tetratricopeptide repeat domain; PPIase; peptidyl-prolyl isomerase; PPI domain; peptidyl-prolyl isomerase domain; MEEVD; amino acid Met, Glu, Glu, Val and Asp; ITC; Isothermal Titration Calorimetry; CD; circular d
Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis
Keywords: AD; activation domain; CGNP; cerebellar granular neuron progenitor cells; CIP; calf intestinal alkaline phosphatase; DB; DNA-binding domain; EGCG; epigallocatechin gallate; FFPE; formalin-fixed, paraffin-embedded; H&E; hematoxylin/eosin staining; Hh; Hedg
Osteogenesis imperfecta: new genes reveal novel mechanisms in bone dysplasia
Keywords: ADAMTS; A disintegrin and metalloprotease with thrombospondin motifs; AR-OI; autosomal recessive osteogenesis imperfecta; ATF6; activating transcription factor 6; ATGL; adipose triglyceride lipase; BiP; binding immunoglobulin protein; BMDD; bone mineraliz
In vivo regulation of human CrkII by cyclophilin A and FK506-binding protein
Keywords: Crk adaptor protein; PPIase; Peptidyl-prolyl cis-trans isomerase; Immunophilins; Cyclophilin A; Cyclosporine A;
Synthesis and Pin1 inhibitory activity of thiazole derivatives
Keywords: Thiazole derivatives; Pin1; Pin1 inhibitor; PPIase; Anti-cancer agents;
Development, synthesis and structure-activity-relationships of inhibitors of the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Burkholderia pseudomallei
Keywords: Mip; macrophage infectivity potentiator; PPIase; peptidyl-prolyl cis/trans isomerase; LpMip; L. pneumophila Mip; BpMip; B. pseudomallei Mip; SAR; structure-activity relationship; HSQC; Heteronuclear Single Quantum Coherence; NMM; N-methylmorpholine; DIP
Structure of inorganic pyrophosphatase from Staphylococcus aureus reveals conformational flexibility of the active site
Keywords: SA; Staphylococcus aureus; PPiase; inorganic pyrophosphatase; PNP; imidodiphosphate; Pyrophosphorolysis; Hydrolase; Phosphate metabolism; Novel drug target; Enzyme; Phosphatase;
Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1
Keywords: AD; Alzheimer's disease; Csd; cysteine sulfinic acid; DNPH; dinitrophenylhydrazine; DTDP; dithiodipyridine; MCI; 4,4â²-mild cognitive impairment; PPIase; peptidyl-prolyl isomerase; Peptidyl-prolyl cis-trans isomerase; Oxidation; Cysteine sulfenic and s
Cyclophilin D and myocardial ischemia-reperfusion injury: A fresh perspective
Keywords: ANT; adenine nucleotide translocator; ATP; adenosine triphosphate; ATP5G; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9); BAK; BCL2-antagonist/killer; BAX; BCL2-associated X protein; BCL-2; B cell lymphoma protein 2; C1QBP
Lettuce (Lactuca sativa L.) leaf-proteome profiles after exposure to cylindrospermopsin and a microcystin-LR/cylindrospermopsin mixture: A concentration-dependent response
Keywords: 2-DE; two-dimensional electrophoresis; APX; ascorbate peroxidase; CHAPS; 3-[(3-cholamidopropyl)dimethylamonio]-1-propanesulfonate; CYN; cylindrospermopsin; EST; expressed sequence tag; FAS; fatty acid synthesis; GSH; glutathione; GST; glutathione-S-transf
Structure-based design of novel human Pin1 inhibitors (III): Optimizing affinity beyond the phosphate recognition pocket
Keywords: Pin1; Peptidyl-prolyl isomerase; PPIase; Phospho-protein epitope; Anti-cancer; Anti-tumor; Mitosis; SBDD; Structural based drug design; Medicinal chemistry; Cell permeability;
Retarded protein folding of the human Z-type α1-antitrypsin variant is suppressed by Cpr2p
Keywords: PPIase; peptidyl-prolyl isomerase; α1-AT; α1-antitrypsin; YPD; 1% yeast extract, 2% peptone, and 2% glucose; YPGal; 1% yeast extract, 2% peptone, and 2% galactose; α1-Antitrypsin; Folding disease; Peptidyl-prolyl isomerase; Protein folding; Protein int
Rapamycin-binding FKBP25 associates with diverse proteins that form large intracellular entities
Keywords: FKBPs; PPIase; FKBP25; Rapamycin; Immunophilin;
Diversified targets of FKBP25 and its complex with rapamycin
Keywords: FKBP; Rapamycin; FKBP25; PPIase; Immunophilin
Genome-wide identification and analysis of FK506-binding protein gene family in peach (Prunus persica)
Keywords: FKBPs; FK506-binding proteins; FKBd; FK506-binding domain; PPIase; peptidyl-prolylcis-trans isomerase; TPR; tetratricopeptide repeat; CaM-BDs; calmodulin-binding domains; SD; single-domain; MD; multidomain; HSP90; heat streak protein 90; CDS; coding seque
Identification and functional analysis of a novel parvulin-type peptidyl-prolyl isomerase from Gossypium hirsutum
Keywords: Gossypium hirsutum; Key amino acids; PPIase; Salt stressPPIase, peptidyl prolyl cis/trans isomerase; GFP, green fluorescence protein; IPTG, isopropyl thio-β-D-galactoside; Gdn-HCl, guanidine hydrochloride; GhPPI, Gossypium hirsutum peptidyl prolyl isomera
Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir
Keywords: EC50; 50% effective inhibitory concentration; CsA/CsD; cyclosporine A/D; PPIase; peptidyl prolyl cis/trans isomerase; CypA/B; cyclophilin A/B; ALV; Alisporivir; FKBP; FK506-binding protein; HCoV-NL63; Cyclosporine/FK506-non-immunosuppressive derivatives;
Genome-wide identification and analysis of FK506-binding protein family gene family in strawberry (Fragaria à ananassa)
Keywords: FKBPs; FK506-binding proteins; FKBd; FK506-binding domain; PPIase; peptidyl-prolylcis-trans isomerase; TPR; tetratricopeptide repeat; CaM-BDs; calmodulin-binding domains; SD; single-domain; MD; multidomain; TOR; target of rapamycin; HSP90; heat streak pro
PPIase independent chaperone-like function of recombinant human Cyclophilin A during arginine kinase refolding
Keywords: ANS; 8-anilino-1-naphthalenesulfonate; CyPA and rhCyPA; cyclophilin A and recombinant human cyclophilin A; CsA; cyclosporin A; PPIase; peptidyl-prolyl cis-trans isomerase; SDS-PAGE; sodium dodecyl sulfate-polyacrylmide gel electrophoresis; Suc-AAP
Dynamic control of the prolyl isomerase function of the dual-domain SlyD protein
Keywords: NMR; Fluorescence; PPIase; FKBP; Dynamics; Enzymology;
FKBP52 is involved in the regulation of SOCE channels in the human platelets and MEG 01 cells
Keywords: Cyps; cyclophilins; FKBPs; immunophilin; FKBP52; FK506 binding protein (52); ER; rough endoplasmic reticulum; SERCA2b; sarco-endoplasmic Ca2Â +-ATPase isotype 2b; IP3R II; inositol 1,4,5-trisphosphate receptor; TRPC; transient receptor potential channel;
Enhancement of antibody fragment secretion into the Escherichia coli periplasm by co-expression with the peptidyl prolyl isomerase, FkpA, in the cytoplasm
Keywords: Fab; fragment-antigen-binding; Fc; fragment crystallizable; Fd; fragment of antibody consisting of CH1 and VH; ScFv; single-chain variable fragment; VH; variable heavy; VL; variable light; PPIase; peptidyl prolyl cis-trans isomerase; PCR; polymerase chain
Differential isolation and identification of PI(3)P and PI(3,5)P2 binding proteins from Arabidopsis thaliana using an agarose-phosphatidylinositol-phosphate affinity chromatography
Keywords: PIP; phosphatidylinositol-phosphate; PI(3)P; phosphatidylinositol-3-phosphate; PI(3,5)P2; phosphatidylinositol-3,5-bisphosphate; PI(3,4,5)P3; phosphatidylinositol-3,4,5-trisphosphate; SUMO; small ubiquitin-like modifier; HSP; heat shock protein; HSF; heat
The roles of phosphate and the phosphate carrier in the mitochondrial permeability transition pore
Keywords: ANT; adenine nucleotide translocase; BKA; bongkrekic acid; CAT; carboxyatractyloside; CRC; calcium retention capacity; CsA; cyclosporine A; CyP-D; cyclophilin-D; PEG; poly(ethylene glycol); IMM; inner mitochondrial membrane; MPT; mitochondrial permeabilit
Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton
Keywords: Benzophenone; Pin1; Pin1 inhibitor; PPIase; Anti-cancer agents;
Research ArticleThe cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection
Keywords: HCV; hepatitis C virus; CsA; cyclosporin A; EC50; 50% effective concentration; HIV-1; Human Immunodeficiency Virus Type-1; PPIase; peptidyl prolyl isomerase; TEAE; treatment-emergent adverse event; CTCAE; Common Terminology Criteria for Adverse Events; IF
The FKBP families of higher plants: Exploring the structures and functions of protein interaction specialists
Keywords: FK506-binding protein; PPIase; Immunophilin; Molecular chaperone; Plant; Stress response; Phosphorylation;
Cyclophilin A affects inflammation, virus elimination and myocardial fibrosis in coxsackievirus B3-induced myocarditis
Keywords: Cyclophilin A; CyPA; EMMPRIN; Extracellular Matrix Metalloproteinase Inducer, CD147; MMP; matrix metalloproteinase; p.i.; post infection; CVB3; coxsackievirus B3; PPIase; peptidylprolylisomerase; CD147; Cyclophilin A; Myocarditis; Inflammation; Fibrosis;
Hsp90 in non-mammalian metazoan model systems
Keywords: PPIase; peptidyl-prolyl cis/trans isomerase; TPR; tetratricopeptide-repeat; Caenorhabditis elegans; Drosophila melanogaster; Danio rerio; Cochaperone; Client; Hsp90;
Dual function of Pin1 in NR4A nuclear receptor activation: Enhanced activity of NR4As and increased Nur77 protein stability
Keywords: CHX; cycloheximide; CK2; protein kinase CK2; DBD; DNA-binding domain; DCOH; dimerization cofactor for hepatocyte nuclear factor 1; GST; glutathione S-transferase; LBD; ligand-binding domain; Pin1; peptidyl-prolyl cis/trans isomerase 1; PPIase; Peptidyl-pr
Mouse FKBP23 mediates conformer-specific functions of BiP by catalyzing Pro117cis/trans isomerization
Keywords: mBiP; mouse immunoglobulin binding protein; ER; endoplasmic reticulum; CyPs; cyclophilins; mFKBP; mouse FK506-binding protein; PPIase; peptidyl-prolyl cis/trans isomerase; Hsp; heat shock protein; mFKBP23N; N-terminus of mFKBP23; mBiPN; N-terminus of mBiP
The crystal structure of the leptospiral hypothetical protein LIC12922 reveals homology with the periplasmic chaperone SurA
Keywords: OMP; outer membrane protein; PPIase; peptidyl prolyl cis-trans isomerase; SeMet; selenomethionine; SAD; single-wavelength anomalous diffraction; PDB; protein data bank; LIC12922; Crystal structure; Parvulin domain; SurA homology; Chaperone;
Synthesis and biological evaluation of novel quinazoline-derived human Pin1 inhibitors
Keywords: Quinazoline; Pin1; Pin1 inhibitor; PPIase; Anti-cancer agents
Management of cytoskeleton architecture by molecular chaperones and immunophilins
Keywords: IMM; immunophilin; FKBP; FK506-binding protein; TPR; tetratricopeptide repeat; PPIase; peptidylprolyl-(cis/trans)-isomerase activity; Hsp; heat-shock protein; sHsp; small Hsp, Hsc, constitutively expressed heat-shock cognate 70-kDa; CHIP; carboxy-terminus
Structural Analysis of Protein Folding by the Long-Chain Archaeal Chaperone FKBP26
Keywords: crystal structure; FKBP; PPIase; prolyl isomerase; protein–protein interactionsPPIase, peptidyl-prolylcis/trans isomerase; FKBP, FK506-binding protein; FKBP26, 26-kDa Methanococcus jannaschii FKBP; TF, trigger factor; IF, Insert-in-Flap domain; CTD, C-ter
Structure-based design of novel human Pin1 inhibitors (II)
Keywords: Pin1; Pin1 inhibitors; Phosphate replacement; PPIase; Anti-cancer agents; SBDD; Carboxylates; Tetrazoles
Enzyme-linked enzyme-binding assay for Pin1 WW domain ligands
Keywords: Pin1; WW domain assay; PPIase; HRP; Chemiluminescent binding assay; Pin1 ligands;