Management of cytoskeleton architecture by molecular chaperones and immunophilins

► Molecular chaperones are housekeeping factors of the cytoskeleton network. ► Cytoprotective roles involve apoptosis inhibition, regulation of organelle homeostasis and protein scaffolding. ► Unlike heat-shock proteins, changes in cytoskeletal filaments in response to stress are tissue-dependent. ► Hsp90 provides biological properties to proteins with a preserved tertiary structure. ► Some TPR-domain immunophilins show antagonistic action on the cytoskeletal organization.