Hsp90 in non-mammalian metazoan model systems

► The first comprehensive summary of Hsp90 literature in non-mammalian metazoan organisms. ► A cross-comparison between different species. ► The beautiful analogy of pathways, which are supported by Hsp90 activity in the three model organisms. ► A summary of the ideas about the origin of phenotypic variability, which was observed as a result of compromised Hsp90 activity. ► An overview of the cochaperone network and its interaction with Hsp90 during the performance of cellular functions.