کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10953984 | 1097829 | 2010 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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![عکس صفحه اول مقاله: Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy](/preview/png/10953984.png)
چکیده انگلیسی
⺠The passive stiffness of skinned HCM cardiac myocytes was similar to that of normal (donor) myocytes. ⺠Maximum Ca-activated force production was reduced by 40% in HCM vs donor myocytes. ⺠This loss of force could contribute to systolic dysfunction in HCM hearts. ⺠Myofibrillar Ca sensitivity was higher in HCM than in donor myocytes. ⺠The enhanced Ca sensitivity could compensate for the smaller maximum force but would tend to cause diastolic dysfunction. ⺠These characteristics were common to all HCM patients studied, suggesting the changes were secondary consequence of the underlying genetic variants.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular and Cellular Cardiology - Volume 49, Issue 5, November 2010, Pages 737-745
Journal: Journal of Molecular and Cellular Cardiology - Volume 49, Issue 5, November 2010, Pages 737-745
نویسندگان
Anita C. Hoskins, Adam Jacques, Sonya C. Bardswell, William J. McKenna, Victor Tsang, Cristobal G. dos Remedios, Elisabeth Ehler, Kim Adams, Shapour Jalilzadeh, Metin Avkiran, Hugh Watkins, Charles Redwood, Steven B. Marston, Jonathan C. Kentish,