Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase

► Impaired Rho-ROCK signaling leads to phosphatidylserine (PS) exposure. ► Impaired Rho-ROCK signaling leads to inhibition of flippase. ► Impaired Rho-ROCK signaling leads to inhibition of Akt. ► Inhibition of Rho leads to both apoptotic and non-apoptotic PS exposure. ► Inhibition of ROCK leads to non-apoptotic PS exposure only.