Angiotensin II inhibits the electrogenic Na+/HCO3− cotransport of cat cardiac myocytes

► Ang II, binding to AT1 receptors, exerts an opposite effect on NBC isoforms. ► nNBC stimulation is mediated by ROS and ERK 1/2. ► p38 kinase mediates the Ang II-induced eNBC inhibition. ► nNBC stimulation may induce intracellular calcium overload. ► eNBC inhibition could lead to action potential prolongation.