Pravastatin normalises peripheral cardiac sympathetic hyperactivity in the spontaneously hypertensive rat

► Pravastatin lowers resting heart rate (HR) in spontaneously hypertensive rats (SHR) ► Cardiac norepinephrine release & tachycardia are reduced by pravastatin in SHRs ► Neuronal NO signalling & NADPH oxidase expression are unchanged by pravastatin ► The effect of pravastatin on sympathetic neurotransmission is reversed by losartan. ► Pravastatin reduces cardiac angiotensin 2 & angiotensin converting enzymes 1 & 2