Impact of long-term caloric restriction on cardiac senescence: Caloric restriction ameliorates cardiac diastolic dysfunction associated with aging

► CR improves LV diastolic function without affecting LV systolic function. CR attenuates the decline in SERCA2 protein and its activity. ► CR ameliorates age-related deterioration of Ca2+ handling during myocyte relaxation. ► CR suppresses the mTOR pathway and enhances autophagic flux in the heart.