Angiotensin II induces afterdepolarizations via reactive oxygen species and calmodulin kinase II signaling

► Ang II induces early afterdepolarizations (EADs) and triggered activities in rabbit myocytes. ► The NADPH oxidase-ROS-calmodulin kinase II (CaMKII) pathway is involved. ► The Ang II-induced EADs are caused by the activation of both ICa,L and late INa mediated by CaMKII. ► These results support a link between renin-angiotensin system and cardiac arrhythmias.