Elevated levels of activated NHE1 protect the myocardium and improve metabolism following ischemia/reperfusion injury

►Expression of activated NHE1 induced cardioprotection with myocardial ischemia/reperfusion. ► Activated NHE1 increased fatty acid oxidation and glycolysis following ischemia reperfusion. ► Transgenic hearts with activated NHE1 had elevated ATP levels following ischemia/reperfusion.