کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10954122 | 1097842 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Changes in oxygen tension affect cardiac mitochondrial respiration rate via changes in the rate of mitochondrial hydrogen peroxide production
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کلمات کلیدی
Succl-NAME - L-NAMEischemic preconditioning - preconditioning ایسکمیکROS - ROSHydrogen peroxide - آب اکسیژنهReperfusion injury - آسیب مجددRespiration - تنفسCardioprotection - حفاظت از قلبdihydroethidium - دی هیدروتیدیمMetabolic rate - سرعت متابولیسمSuccinate - سوکینتینOxygen consumption - مصرف اکسیژنMitochondria - میتوکندریاH2O2 - هیدروژن پراکسیدHypoxia - هیپوکسیDHE - وglutamate/malate - گلوتامات / مالاتReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The capacity of mitochondria to respond to changes in oxygen delivery has the potential to affect the ability of the heart to tolerate decreased oxygen delivery. Respiration by mitochondria is typically regarded as independent of oxygen tension (pO2) until critically low oxygen concentrations limit the activity of cytochrome oxidase. Paradoxically, there is evidence that cellular and mitochondrial oxygen consumption (respiration) can decline at oxygen tensions well above this critical pO2. We tested the hypothesis that oxygen sensitive decreases in mitochondrial hydrogen peroxide production can decrease cardiac mitochondrial respiration rate. Consistent with previous work, an acute decline in pO2 from 146Â mm Hg to 10-13Â mm Hg in less than 10Â min did not affect mitochondrial respiration rate. In contrast, sustained incubation of mitochondria at a pO2 of 10-13Â mm Hg for 30Â min caused a 50% decrease in mitochondrial respiration rate. This decrease in mitochondrial respiration rate was mimicked by incubation with the hydrogen peroxide scavenger catalase and the decrease in mitochondrial respiration rate was fully reversible by reintroducing oxygen or by adding hydrogen peroxide. Incubation at low pO2 was also associated with a decreased rate of mitochondrial reactive oxygen species production. These findings indicate that oxygen-dependent decreases in the rate of mitochondrial hydrogen peroxide production can decrease cardiac mitochondrial respiration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular and Cellular Cardiology - Volume 47, Issue 1, July 2009, Pages 49-56
Journal: Journal of Molecular and Cellular Cardiology - Volume 47, Issue 1, July 2009, Pages 49-56
نویسندگان
Carla A. Di Maria, Marie A. Bogoyevitch, Douglas J. McKitrick, Leonard F. Arnolda, Livia C. Hool, Peter G. Arthur,