کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10954410 | 1097902 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
KATP channel therapeutics at the bedside
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کلمات کلیدی
SUR2Kir6.2KIR6.1SUR1 - sur1Asthma - آسمalopecia - آلوپسی، ریزش موAngina pectoris - آنژین پکتیکسPeripheral vascular disease - بیماری عروقی محیطیischemic heart disease - بیماری قلبی ایسکمیکHypertension - فشار خون بالاNeuroprotection - محافظت نورونی یا محافظت از عصبimpotence - ناتوانی جنسیATP-sensitive K+ channels - کانال های K + حساس به ATP
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The family of potassium channel openers regroups drugs that share the property of activating adenosine triphosphate-sensitive potassium (KATP) channels, metabolic sensors responsible for adjusting membrane potential-dependent functions to match cellular energetic demands. KATP channels, widely represented in metabolically-active tissue, are heteromultimers composed of an inwardly rectifying potassium channel pore and a regulatory sulfonylurea receptor subunit, the site of action of potassium channel opening drugs that promote channel activity by antagonizing ATP-induced pore inhibition. The activity of KATP channels is critical in the cardiovascular adaptive response to stress, maintenance of neuronal electrical stability, and hormonal homeostasis. Thereby, KATP channel openers have a unique therapeutic spectrum, ranging from applications in myopreservation and vasodilatation in patients with heart or vascular disease to potential clinical use as bronchodilators, bladder relaxants, islet cell protector, antiepileptics and promoters of hair growth. While the current experience in practice with potassium channel openers remains limited, multitude of ongoing investigations aims at defining the benefit of this emerging family of therapeutics in diverse disease conditions associated with metabolic distress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular and Cellular Cardiology - Volume 39, Issue 1, July 2005, Pages 99-112
Journal: Journal of Molecular and Cellular Cardiology - Volume 39, Issue 1, July 2005, Pages 99-112
نویسندگان
A. Jahangir, Andre Terzic,