Analysis of LIN28A in early human ovary development and as a candidate gene for primary ovarian insufficiency

► Lin28 proteins regulate micro RNAs and are implicated in germ cell development. ► We assessed LIN28A and LIN28B in the early human ovary and testis. ► Expression of LIN28A increases in the developing ovary between 6 and 9 weeks conception. ► Expression of LIN28B was lower and did not change. ► Alterations in LIN28A were not found in women with primary ovarian insufficiency.