Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer

► Testicular germ cell cancer (TGCC) has a significant, multi-genetic component. ► We aim to identify additional risk alleles associated with TGCC. ► SNPs in ESR1, ESR2, and LHCGR associate with features of TGCC. ► SNPs in ESR1 and LHCGR are predictors of hormone levels in healthy subjects. ► Genetic polymorphisms in ESR1, ESR2 and LHCGR contribute to the aetiology of TGCC.