کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10956296 1098825 2012 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nuclear retinoic acid receptors: Conductors of the retinoic acid symphony during development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Nuclear retinoic acid receptors: Conductors of the retinoic acid symphony during development
چکیده انگلیسی
The vitamin A derivative, retinoic acid (RA), is essential for embryonic development through the activation of cognate nuclear receptors, RARs, which work as ligand dependent regulators of transcription. In vitro studies revealed how RARs control gene expression at the molecular level and now it appears that it is fine-tuned by a phosphorylation code. In addition, several genetic approaches provided valuable insights on the functions of RARs during development and on the influence of other actors such as the enzymes involved in RA synthesis and degradation and other signaling pathways. It appears that RARs are the conductors of the RA signaling symphony through controlling the dynamics and the coordination of the different players and development steps.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 348, Issue 2, 30 January 2012, Pages 348-360
نویسندگان
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