کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10956741 | 1099444 | 2007 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cadherin inhibition of β-catenin signaling regulates the proliferation and differentiation of neural precursor cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
The generation and differentiation of neurons during development requires coordination of intercellular interactions with spatio-temporal changes in gene expression. To examine the role of adhesion in cerebral cortical development, we overexpressed full-length cadherin and dominant-negative truncated cadherin in mouse cortical precursors. Full-length cadherin allowed for the maintenance of cell contact between daughter cells following cell division while dominant-negative cadherin decreased cell contact. Paradoxically, both cadherin isoforms inhibited precursor proliferation, induced premature neuronal differentiation, and inhibited β-catenin dependent signaling. Furthermore, alteration of cadherin or β-catenin function led to additional changes in precursor identity and division symmetry as demonstrated by altered expression of the radial glial marker, Pax6, and the intermediate precursor marker, Tbr2. Moreover, clonal analysis demonstrated asymmetric distribution of Tbr2 following precursor mitosis. Together, these results show that cadherins affect neural precursor fate determination through a cell-autonomous regulation of catenin signaling distinct from cadherin adhesive function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Neuroscience - Volume 35, Issue 4, August 2007, Pages 549-558
Journal: Molecular and Cellular Neuroscience - Volume 35, Issue 4, August 2007, Pages 549-558
نویسندگان
Stephanie R. Noles, Anjen Chenn,