کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10958041 | 1099961 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Systemic pregabalin attenuates facial hypersensitivity and noxious stimulus-evoked release of glutamate in medullary dorsal horn in a rodent model of trigeminal neuropathic pain
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کلمات کلیدی
i.v.MDHi.p.standard error of the mean - خطای استاندارد میانگینTooth pulp - خمیر دندانintraperitoneal - داخل صفاقیIntravenous - داخل وریدیNeuropathic pain - درد نوروپاتیکmustard oil - روغن خردلmedullary dorsal horn - شاخ پشتی مدولارnociception - غربالگریCSF - مایع مغزی نخاعیCerebrospinal fluid - مایع مغزی نخاعیSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیPregabalin - پرگابالینhigh performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کاراglutamate - گلوتامات
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Pregabalin is effective in treating many neuropathic pain conditions. However, the mechanisms of its analgesic effects remain poorly understood. The aim of the present study was to determine whether pregabalin suppresses facial mechanical hypersensitivity and evoked glutamate release in the medullary dorsal horn (MDH) in a rodent model of trigeminal neuropathic pain. Nociceptive mechanical sensitivity was assessed pre-operatively, and then post-operatively 1Â h following pregabalin or vehicle (saline) treatment on post-operative days 2 and 5 following infraorbital nerve transection (IONX). In addition, an in vivo microdialysis probe was inserted into the exposed medulla post-operatively and dialysate samples were collected. Glutamate release was then evoked by mustard oil (MO) application to the tooth pulp, and the effects of pregabalin or vehicle were examined on the MDH glutamate release. Glutamate concentrations in the dialysated samples were determined by HPLC, and data analyzed by ANOVA. IONX animals (but not control animals) showed facial mechanical hypersensitivity for several days post-operatively. In addition, tooth pulp stimulation with MO evoked a transient release of glutamate in the MDH of IONX animals. Compared to vehicle, administration of pregabalin significantly attenuated the facial mechanical hypersensitivity as well as the MO-evoked glutamate release in MDH. This study provides evidence in support of recent findings pointing to the usefulness of pregabalin in the treatment of orofacial neuropathic pain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochemistry International - Volume 62, Issue 6, May 2013, Pages 831-835
Journal: Neurochemistry International - Volume 62, Issue 6, May 2013, Pages 831-835
نویسندگان
Naresh Kumar, Pavel S. Cherkas, Vidya Varathan, Makiko Miyamoto, Chen Yu Chiang, Jonathan O. Dostrovsky, Barry J. Sessle, Terence J. Coderre,