Expression and activity of PARP family members in the hippocampus during systemic inflammation: Their role in the regulation of prooxidative genes

► We studied the PARP family in the brain during systemic inflammatory response SIR. ► SIR significantly enhanced gene expression and activity of PARP family members. ► Inhibition of PARP prevented SIR-induced poly(ADP-ribosylation) in the hippocampus. ► Inhibition of PARP prevented SIR-induced NF-κB-related expression of the Nos2 gene. ► Inhibition of PARP offers a promising strategy in inflammation-related conditions.