Ginsenoside Rg1 facilitates neural differentiation of mouse embryonic stem cells via GR-dependent signaling pathway

► Ginsenoside Rg1 facilitates neural differentiation of mouse ES cells. ► Activation of GR contributes to the neurogenetic effect of Rg1. ► MEK-ERK1/2 and PI3 K-Akt pathways are both involved in Rg1 neurodifferentiation.