Oligomeric amyloid-β peptide affects the expression of genes involved in steroid and lipid metabolism in primary neurons

► Microarray study of primary mouse cortical neurons treated with oligomeric Aβ1-42 (ADDLs). ► Down-regulation of genes involved in the biosynthesis of cholesterol and other steroids/lipids. ► Abca1, involved in cholesterol transport and linked to Alzheimer's, up-regulated. ► Interactions between Aβ and cholesterol potentially important in Alzheimer's pathology.