Accumbal dopamine, noradrenaline and serotonin activity after naloxone-conditioned place aversion in morphine-dependent mice

► We evaluate the role of monoamines in naloxone-induced conditioned place aversion (CPA). ► We examined changes in the turnover of DA, NA and 5-HT in the nucleus accumbens (NAc). ► We examine the changes in TH mRNA in the ventral tegmental area (VTA). ► Morphine withdrawal Increases NA and DA turnover in NAc and elevates TH expression in VTA. ► CPA is related to NA and DA activity and transcriptional regulation of TH.