Presenilin 1 and 2 are expressed differentially in the cerebral cortex of mice during development

► We examine expression of PS1 and PS2 in mouse cerebral cortex during development. ► We also study their regional distribution in cerebral cortex during development. ► PS1 and PS2 show differential expression in prenatal, neonatal and postnatal stages. ► We demonstrate for the first time that PS2 expression alters during development. ► Their distribution patterns change during development without regional variation.