The perineuronal net component of the extracellular matrix in plasticity and epilepsy

► Composition of the extracellular matrix of the central nervous system. ► Specialized perineuronal net component of matrix found around interneurons. ► During development neuronal activity is required for perineuronal net expression. ► Perineuronal net leads to decreased plasticity in adult central nervous system. ► Extracellular matrix and perineuronal net are altered during epileptogenesis.