Amelioration of intracerebroventricular streptozotocin induced cognitive impairment by Evolvulus alsinoides in rats: In vitro and in vivo evidence

► Hydro-alcoholic extract of Evolvulus alsinoides showed more enzymes inhibitory activity in vitro. ► Hydro-alcoholic extract of E. alsinoides ameliorated ICV-STZ induced cognitive impairment. ► Hydro-alcoholic extract of E. alsinoides decreased the oxidative stress. ► Cholinesterase activity was reduced by hydro-alcoholic extract of E. alsinoides. ► Hydro-alcoholic extract of E. alsinoides decreased ROCK II expression.