Tianeptine potentiates AMPA receptors by activating CaMKII and PKA via the p38, p42/44 MAPK and JNK pathways

► The antidepressant Tianeptine enhances AMPA but not NMDA receptor function in the CA1. ► Tianeptine induces phosphorylation of GluA1 but not NA1 in the hippocampus. ► Tianeptine activates CaMKII, PKA and the p38, p42/44 JNK pathways.