Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model

► Autophagosome formation is promoted by PINK1 silencing in mouse striatum. ► PP2A inactivation via phosphorylation (Y307) is involved in this autophagic pathway. ► Dissociation of Beclin1/Bcl-2 via p-Bcl-2-S87 is regulated by PP2A inactivation. ► PP2A-inactivation-mediated autophagy is protective against PINK1 dysfuction.