Neuroprotective effect of pyruvate and oxaloacetate during pilocarpine induced status epilepticus in rats

▶ Treatment with pyruvate and oxaloacetate could be neuroprotective during status epilepticus ▶ Status epilepticus was induced by pilocarpine in rats. ▶ Hippocampal neuronal loss in CA1 was completely prevented ▶ Hippocampal caspase-1 activation was significantly reduced.