کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10958359 | 1100016 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Glutamate-dependent phosphorylation of the mammalian target of rapamycin (mTOR) in Bergmann glial cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Glutamate-dependent phosphorylation of the mammalian target of rapamycin (mTOR) in Bergmann glial cells Glutamate-dependent phosphorylation of the mammalian target of rapamycin (mTOR) in Bergmann glial cells](/preview/png/10958359.png)
چکیده انگلیسی
Glutamate, the major excitatory neurotransmitter in the mammalian central nervous system, plays an important role in neuronal development and synaptic plasticity. It activates a variety of signaling pathways that regulate gene expression at the transcriptional and translational levels. Within glial cells, besides transcription, glutamate also regulates translation initiation and elongation. The mammalian target of rapamycin (mTOR), a key participant in the translation process, represents an important regulatory locus for translational control. Therefore, in the present communication we sought to characterize the mTOR phosphorylation pattern after glutamate treatment in chick cerebellar Bergmann glia primary cultures. A time- and dose-dependent increase in mTOR Ser 2448 phosphorylation was found. Pharmacological tools established that the glutamate effect is mediated through ionotropic and metabotropic receptors and interestingly, the glutamate transporter system is also involved. The signaling cascade triggered by glutamate includes an increase in intracellular Ca2+ levels, and the activation of the p60Src/PI-3K/PKB pathway. These results suggest that glia cells participate in the activity-dependent change in the brain protein repertoire.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochemistry International - Volume 55, Issue 5, October 2009, Pages 282-287
Journal: Neurochemistry International - Volume 55, Issue 5, October 2009, Pages 282-287
نویسندگان
Rossana C. Zepeda, Iliana Barrera, Francisco Castelán, Edna Suárez-Pozos, Yaaziel Melgarejo, Elba González-Mejia, Luisa C. Hernández-Kelly, Esther López-Bayghen, José Aguilera, Arturo Ortega,