Crosstalk between the developing pancreas and its blood vessels: An evolving dialog

► Blood vessels influence pancreas organogenesis and differentiation of its cell lineages. ► Aortic endothelial cells are required for early endocrine specification. ► Blood vessels suppress later pancreatic branching and exocrine differentiation. ► Understanding how blood vessels impact the developing pancreas and identifying candidate signals may improve replacement and regenerative therapies for diabetes.