Nuclear translocation and functions of growth factor receptors

► This review focuses on nuclear trafficking and functions of growth factor receptors, principally members of the ErbB family. ► It discusses the pathways and signals which contribute to nuclear translocation of these receptors. ► It outlines the functions of nuclear growth factor receptors. ► It describes the application made of these observations to determining cancer prognosis and treatment response. ► It defines the challenges of further exploring the nuclear trafficking and functions of growth factor receptors.