کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10959206 | 1100406 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Coordination of intracellular transport steps by GTPases
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Coordination of intracellular transport steps by GTPases Coordination of intracellular transport steps by GTPases](/preview/png/10959206.png)
چکیده انگلیسی
Coordination of transport steps between intracellular compartments is important for ensuring unobstructed traffic flow while maintaining compartment size. Small GTPases from the Rab, Arf and Rho families, which regulate individual transport steps, have also emerged as coordinators of these steps. Here, I summarize evidence supporting the existence of GTPase-dependent transport step coordination at three levels: maturation of two cellular sorting compartments, Golgi and endosomes; coupling of vesicular transport sub-steps between donor and acceptor compartments; and integration of transport steps into whole pathways. The mechanisms proposed for GTPase-mediated transport-step coordination depend on the ability of single GTPases to interact with multiple effectors and on interactions of multiple GTPases through common accessory factors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 22, Issue 1, February 2011, Pages 33-38
Journal: Seminars in Cell & Developmental Biology - Volume 22, Issue 1, February 2011, Pages 33-38
نویسندگان
Nava Segev,